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M9550076.TXT
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1995-03-04
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Document 0076
DOCN M9550076
TI Routine vaccination in HIV-infected patients: a review.
DT 9505
AU Borleffs JC; Schneider MM; Department of Internal Medicine, Utrecht
University Hospital,; Netherlands.
SO Neth J Med. 1994 Dec;45(6):244-9. Unique Identifier : AIDSLINE
MED/95140114
AB This paper reviews the literature from 1988 to November 1993 on the
effectiveness of routine vaccination of HIV-infected adults. Data on the
clinical benefit of vaccination in this particular group of patients are
not available. In general, HIV-infected patients have suboptimal
immunological responses to vaccines. In particular, an impaired
responsiveness is found in patients with fewer than 200 x 10(6) CD4+
cells per litre. Consequently, it seems prudent to offer active
immunization to HIV-infected subjects who are relatively
immunocompetent. However, the usefulness of vaccination in those
subjects who have a low CD4+ cell count is doubtful.
DE Human HIV Infections/BLOOD/IMMUNOLOGY/*THERAPY *Vaccination/ADVERSE
EFFECTS/METHODS JOURNAL ARTICLE REVIEW REVIEW, TUTORIAL
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).